Leptin receptor gene polymorphisms and several polymorphisms of leptin gene (lep) and leptin and lys109arg polymorphisms with obesity and overweight in an iranian young population. Two of the most important genes in this respect are the leptin gene and the corresponding leptin receptor gene leptin is a peptide that is secreted by adipose tissue ( 5 zhang i , proenca r , maffei m , barone m , leopold l , friedman jm. Single nucleotide mutations of the leptin gene (resulting in a truncated protein) or the leptin receptor (lepr) gene (resulting in a premature termination of the intracellular domain) are responsible for the morbid obesity seen in mouse models of obesity (ob/ob and db/db mice, respectively) (7, 8) as well as a few rare cases of obesity in humans (9-11. Leptin receptor (lepr) and estrogen receptor a(era) genes in young men design: bmd, anthropometric characteristics, and serum leptin concentrations were measured in young men and compared with. There was a significant increase in the leptin gene (aa genotype) and the leptin receptor gene (rr genotype) in hfnef patients compared to the control group leptin levels, leptin gene (aa genotype) and lepr (rr genotype) were more associated with nyha iii than with nyha i and ii.
Fan sh, say yh leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic malaysian suburban population j physiol anthropol 201433:15 view article pubmed pubmed central google scholar rosmond r association studies of genetic polymorphisms in central obesity: a critical review. Leptin receptor also known as lep-r or ob-r is a type i cytokine receptor, a protein that in humans is encoded by the lepr gene lep-r functions as a receptor for the fat cell-specific hormone leptin. Dataset | omimsnp annotations reformated galaxy dataset ' omimsnp annotations reformated. Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic malaysian suburban population j physiol anthropol 2014 33 :15 doi: 101186/1880-6805-33-15.
If polymorphisms in the leptin receptor play a role in the leptin signaling, it is likely that the association between leptin and weight gain is modified by mutations in the lepr gene however, table 6 shows that the associations between leptin and risk for weight gain were not clearly modified by these mutations. The genetic variation in the response to saccharin and dilute sucrose solutions is largely explained by polymorphisms in the tas1r3 gene that encodes for the t1r3 sweet receptor read more the obesity gene negr1 is associated with white matter integrity in healthy young adults. Oa text is an independent open-access scientific publisher showcases innovative research and ideas aimed at improving health by linking research and practice to the benefit of society.
Two polymorphisms in the leptin gene promoter (-2548 g/a, +19 g/a) and three amino acid sequence-changing polymorphisms in the leptin receptor-encoding gene (k109r a/g, q223r a/g, k656n g/c) were studied. Several epidemiological studies have been conducted to examine the association between leptin and leptin receptor (lepr) gene polymorphisms and risk of obstructive sleep apnea (osa) however, the results remain conflicting rather than conclusive we carried out a search in medline, embase, and. Leptin (lep) is a well known anti-obesity hormone that regulates body weight through its eﬀects on food intake and energy expenditure (zhang et al 1994 halaas et al. Leptin receptor gene g223r polymorphism in young urban sri lankan women 1440 words | 6 pages leptin receptor gene q223r polymorphism in young urban sri lankan women introduction overweight and obesity result from fat accumulation in adipose tissue which is an important fact occur in result of energy imbalance and associated with many chronic diseases. Mutations of leptin gene resulting in leptin deficiency cause obesity, insulin resistance, and diabetes in animals and, in few cases, morbid obesity and hyperinsulinemia in humansthe distribution of single nucleotide polymorphism of the leptin receptor gene lepr rs1137101( (q223r) in the slavonic population (ukrainian and russian) from kharkov and poltava was investigated.
Methods data from the isle of wight birth cohort (iow n = 1456, aged 18 years) and kuwait university allergy (kua n = 1154, aged 18-26 years) studies were analyzed acetamino. The mutation in leptin receptor (lepr) gene causes splicing abnormality that resulted in truncated receptor, aberrant signal transduction, leptin resistance, and obesity this study aims to determine the association of lepr gene polymorphisms, rs1137100 and rs1137101, on phenotype and leptin level between obese and control groups in yogyakarta. Ma x-j, guo -h-h, hao s-w, sun s-x, yang x-c, yu b, et al [association of single nucleotide polymorphisms (snps) in leptin receptor gene with knee osteoarthritis in the ningxia hui population], in chinese.
Several polymorphisms in leptin gene and its receptor gene have been related to breast cancer, such as -2548 g/a and q223r, because -2548 g/a polymorphism in the promoter of leptin gene can affect the expression of this gene and q223r polymorphism in leptin receptor gene is associated with impaired binding of leptin to its receptor, affecting. The human leptin receptor is a member of the class i cytokine receptor family that stimulates gene transcription through activation of stat proteins it has one long and three short isoforms [ 12 ] within the coding sequence of the long isoform, five common sequence variants have been described [ 17 ] table 1 . The relationship between-2548 g/a leptin gene polymorphism and risk of breast cancer and serum leptin levels in ahvazian women iran j cancer prev 2015 8:100-108 38 woo hy, park h, ki cs, park yl, bae wg relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in korea cancer lett 2006 237:137-142 39. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (lepr) genes, we analysed the frequencies of the -2548 g/a and +19 g/a lep, as well as the k109r, q223r, and k656n lepr polymorphisms in centenarians and in control groups.
Vasoactive intestinal peptide receptor 1 vipr1 pg95s ggt=agt cg283a synovial sarcoma translocation gene on chromosome 18-like 1 ss18l1 pl253p ctc=ccc ct758c. In this study, we reported no association between the lep g-2548a polymorphism in the leptin gene and lepr q223r polymorphism in the leptin receptor gene and obesity, in a sample of the romanian population. Background this study was to investigate the prevalence of single nucleotide polymorphisms (snps) in leptin gene lep (a19g and g2548a) and leptin receptor gene lepr (k109r and q223r) and their association with fasting plasma leptin level (pll) and obesity in a malaysian suburban population in kampar, perak.